The Association of Triglyceride to High-Density Lipoprotein Cholesterol Ratio with High-Risk Coronary Plaque Characteristics Determined by CT Angiography and Its Risk of Coronary Heart Disease

This study found that a high ratio of triglycerides (TG) to high-density lipoprotein cholesterol (HDL-C) was significantly associated with the presence of high-risk coronary plaques, which may predict future acute coronary syndrome, in patients with suspected coronary artery disease (CAD). This ratio was also shown to be a significant predictor of adverse coronary events after adjusting for traditional risk factors, suggesting that it may be a useful biomarker for assessing CAD risk. Elevated TG/HDL-C values have been linked to metabolic syndrome, insulin resistance, and pre-diabetic states, and are positively correlated with insulin resistance. The relationship between the TG/HDL-C ratio and CAD-related outcomes has been demonstrated in both the general population and in high-risk patients with known CAD. Lifestyle modification, such as increased physical activity and weight loss, is the first step in managing patients with a high TG/HDL-C ratio, with pharmacological interventions considered if these measures are not sufficient.

Koide Y, Miyoshi T, Nishihara T, Nakashima M, Ichikawa K, Miki T, Osawa K, Ito H. The Association of Triglyceride to High-Density Lipoprotein Cholesterol Ratio with High-Risk Coronary Plaque Characteristics Determined by CT Angiography and Its Risk of Coronary Heart Disease. Journal of Cardiovascular Development and Disease. 2022; 9(10):329. https://doi.org/10.3390/jcdd9100329