Association of Plasma High-Density Lipoprotein Cholesterol Level With Risk of Fractures in Healthy Older Adults

This is a post-hoc analysis of the ASPREE clinical trial that aimed to determine the relationship between high-density lipoprotein cholesterol (HDL-C) levels and fracture risk in healthy older adults. The study used data from 16,703 Australians and 2,411 US participants aged ≥70 and ≥65 years respectively, who were free from cardiovascular disease, dementia, physical disability, and life-limiting chronic illness. The results showed that each 1-SD increase in HDL-C levels was linked to a 14% higher risk of fractures, as confirmed by medical imaging. The association persisted after controlling for various factors such as osteoporosis medication use, smoking, alcohol consumption, physical activity, and statin use. No association was found between non-HDL-C levels and fractures. The findings indicate that higher HDL-C levels are associated with an increased risk of fractures.

https://jamanetwork.com/journals/jamacardiology/fullarticle/2800308?guestAccessKey=297b753c-9e25-4ec5-a7d2-1300444d13d9&utm_content=weekly_highlights&utm_term=012923&utm_source=silverchair&utm_campaign=jama_network&cmp=1&utm_medium=email


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